14-05-2022, 05:49 PM
https://ergo-log.com/the-calming-effect-of-tamoxifen.html
Tamoxifen, the active ingredient in the antioestrogenic drug Nolvadex, makes you calmer. So calm in fact that psychiatrists would like to use tamoxifen to treat manias. According to an animal study done by pharmacologists at the Universidade Federal do Parana in Brazil, tamoxifen can even negate the mental effects of amphetamines.
How tamoxifen fights mania
Question: how are medicines such as lithium and valproate capable of treating mania, the hyperactive condition that can arise from a psychiatric disorder or drugs use?
Answer: because they inhibit the enzyme protein kinase C in brain cells. As does tamoxifen, a substance that is marketed for its ability to deactivate the sex hormone estradiol and is therefore popular among chemical athletes who notice that the steroids they are using are having oestrogenic side effects.
Human study
In the late 1990s the American psychiatrist Joseph Bebchuk discovered that tamoxifen was also capable of fighting manias in people with bipolar disorder. [Arch Gen Psychiatry. 2008 Mar; 65(3): 255-63.] Bebchuk's study was small, but since then bigger studies have confirmed his results. One of these was done at Dokuz Eylul University in Turkey. The figure reproduced below comes from this study.
It shows the effect of a hefty course of tamoxifen [the researchers built up the dose over a week to 80 mg per day] on mania, measured using two different methods. The effect is comparable with that of lithium and valproate, the Turks claim in their publication.
Tamoxifen, the active ingredient in the antioestrogenic drug Nolvadex, makes you calmer. So calm in fact that psychiatrists would like to use tamoxifen to treat manias. According to an animal study done by pharmacologists at the Universidade Federal do Parana in Brazil, tamoxifen can even negate the mental effects of amphetamines.
How tamoxifen fights mania
Question: how are medicines such as lithium and valproate capable of treating mania, the hyperactive condition that can arise from a psychiatric disorder or drugs use?
Answer: because they inhibit the enzyme protein kinase C in brain cells. As does tamoxifen, a substance that is marketed for its ability to deactivate the sex hormone estradiol and is therefore popular among chemical athletes who notice that the steroids they are using are having oestrogenic side effects.
Human study
In the late 1990s the American psychiatrist Joseph Bebchuk discovered that tamoxifen was also capable of fighting manias in people with bipolar disorder. [Arch Gen Psychiatry. 2008 Mar; 65(3): 255-63.] Bebchuk's study was small, but since then bigger studies have confirmed his results. One of these was done at Dokuz Eylul University in Turkey. The figure reproduced below comes from this study.
It shows the effect of a hefty course of tamoxifen [the researchers built up the dose over a week to 80 mg per day] on mania, measured using two different methods. The effect is comparable with that of lithium and valproate, the Turks claim in their publication.
